PHYSIOLOGY AND PATHOPHYSIOLOGY OF PROTEINASE-ACTIVATED RECEPTORS (PARS): PAR-2 AS A POTENTIAL THERAPEUTIC TARGET

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic Target

PAR-2 is the second member of the family of proteinase-activated receptors activated by trypsin, tryptase, and several other serine proteinases.In order to evaluate the therapeutic potential for PAR-2, we have performed studies on PAR-2-mediated signal transduction and investigated the effects of PAR-2 gene deficiency in disease models.In addition

read more

Clinical profile, treatment received, follow up and current status of individuals treated for delusional disorder at a tertiary care centre

Background Delusional disorder presents with a stable and well-defined delusional system.Many are unwilling to accept that they have a mental disorder or that they require psychiatric treatment.The condition responds to Coolers treatment in most cases.This study aims to assess the clinical profile, treatment pattern and response to it, frequency of

read more

Interreligious dialogue as a myth

The authors aim in this article to show why it is extremely difficult to expect representatives of missionary religions to engage in productive interreligious dialogue.The article demonstrates how the imperative to convert, which is rooted in a sense of epistemic authority that one holds the best version of truth, precludes interreligious dialogue

read more

Molecular Characterization and Pathological Findings of Syngamus trachea in Captive White Storks in University of Ibadan Zoological Garden, Nigeria

This case report highlights the clinical presentation, postmortem findings, and diagnostic evaluation of syngamosis and severe dehydration in two white storks (Ciconia ciconia).The storks, a male Hairclip and female, introduced into a zoo four months prior, succumbed to parasitic tracheitis and dehydration.Necropsy and histopathology examinations w

read more